Natural products are not only the basis and source of new drug research and development. Natural product total synthesis is also a very important way to learn and combine the knowledge of basic organic chemistry, advance organic chemistry, mechanisms, organometallics, medicinal chemistry, name reaction, asymmetric synthesis, synthesis strategy and other areas. This course will focus on more than a dozen representative of the natural product synthesis, from the introduction of the overall synthesis of ideas and strategies, carefully explained in detail the reasons behind the transformation and mechanism, so that students have a comprehensive understanding of organic chemistry of the mastery, greatly promoting the future and career skill for the students.