Proteins are the mostversatile macromolecules in living systems and serve crucial functions inessentially all biological processes. Our aim is to teach the structure bases,methods to determine structures and the basic principles governing proteinstructure-function relationship. With this course, students will have afundamental understanding of the structure and function of proteins, an atomicoverview of our living system, as well as knowledge and skills to solveproblems in biological and medical research.