肿瘤生物学原理 (董金堂)MED3332022秋 2021秋 2021春  
2022秋 2021秋 2021春
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选课类别:专业任务 教学语言:双语
课程类别:专业选修课 开课单位:医学院
课程层次:本科 获得学分:3.0
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课程简介(教工部数据)
本课程通过理论讲授,首先了解癌症的发生率和死亡率、组织病理和临床特点以及生物学特征。然后掌握肿瘤生物学的各种概念和原理,包括癌细胞永生化、增殖和生存;癌基因;肿瘤抑制基因;癌症的起因、DNA损伤修复以及遗传与表观遗传改变;化学癌变以及癌症的多步骤多阶段特点;物理和生物因子诱导的癌变;癌症发生的遗传因素;浸润和肿瘤转移;肿瘤微环境和免疫逃逸;组学和肿瘤信号网络;干细胞和癌症的细胞起源;癌的其他特征:血管新生和癌细胞代谢;癌症的筛查、诊断和治疗;癌症预防。


Via classroom teaching, students will learn basic information about cancer, including cancer incidence and mortality, histopathologic and clinical features of cancer, and biological hallmarks of cancer. Students will then grasp concepts and principles of cancer biology, including cancer cell immortalization, proliferation, and survival; oncogenes; tumor suppressor genes; causes of cancer, DNA damage and repair, and genetic/epigenetic alterations; chemical carcinogenesis and multistep and multifactor nature of cancer; physical and biological carcinogenesis; hereditary factors in cancer development; invasion and cancer metastasis; tumor microenvironment and immune evasion; omics and cancer signaling network; stem cells and the cellular origin of cancer; other hallmarks of cancer – angiogenesis and cancer metabolism; cancer screening, diagnosis, and treatment; and cancer prevention.
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董金堂

人类细胞生物和遗传学系

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