Hearing science is a highly interdisciplinary subject that combines the knowledge and technology of multiple disciplines. From the early study of cochlear mechanics, although it is part of the mechanics, its experimental measurement combined with the advanced optical technology of the stroboscopic microscope at that time, and the mathematical model of it used a circuit implementation; 40 years ago, the application of electrophysiological technology helped the discovery of the electrical motility of outer hair cells and its molecular bases, Prestin, a protein with unique piezoelectric properties; to the latest use of two-photon fluorescence microscope to observe the microstructure of the tympanic membrane, and the use of virus vectors to apply CrispCase9 technology to treat gene-defect mice. All advances in auditory science are related to the application of the latest technologies in other disciplines. This course takes these important discoveries in hearing science as examples, hoping to inspire students to carry out interdisciplinary research.