This course aims to create an excellent national course, and is offered to freshmen undergraduates. This course starts from the intellisense technology in the era of artificial intelligence,teaches the knowledge of basic principles, sensor signal processing, sensor packaging, sensor network and other knowledge. Furthermore, the course introduces applications of intellisense technique in petrochemical industry, biochemistry, and defense fields. The course could enhance students' scientific critical thinking, enable students to integrate theory with practice, and cultivate high-level compound talents for the country's future development of information fields.