The elective course introduces the essential concept, methods and principles of evidence based medicine (EBM) which is indispensable for clinical study. Also, it will introduce the knowledge of clinical trial, based on the comprehension of clinical epidemiology and EBM. The course focuses on cultivating the students' ability of clinical research, to master the basic principles and methodology of clinical research, and to use EBM to guide their future clinical work. It also enhances the students’ capability to conduct clinical trials and other medical studies. The lecturer himself has many years’ experience of clinical trial, who can provide professional and colorful teaching for medical students. The course aims to train the medical students to become researcher-doctors an physician-scientists.