生物物理前沿

(闫凯歌)BIO70062024春 2023春 2022春  
2024春 2023春 2022春
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选课类别:专业任务 教学语言:中文
课程类别:专业选修课 开课单位:生物系
课程层次:未知 获得学分:3.0
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课程简介(教工部数据)
生物物理学前沿是一门介绍如何将物理学规律和方法应用于生物学研究的课程,目标是通过对生命过程的定量分析,建立简单的生物物理模型,拓展学生对生物物理研究的视野,加深其对生物大分子功能及其调控的理解,从而帮助学生建立更完善的知识体系,夯实科研基础。我们将从引入一些事实数据开始,获得对生物现象的定量理解。接下来,我们将研究生物膜的物理和化学特性、生物系统能量传递和运动特征。然后,我们将重点讲解一系列推动研究蛋白质和核酸的结构和功能的进展的技术。最后,我们将介绍蛋白质折叠机制,回顾淀粉样蛋白丝研究的进展以及由液-液相分离驱动的蛋白质集聚研究进展。


Frontiersin Biophysics is a course that introduces how to apply the laws and methods ofphysics to biological research. The goal is to expand students' vision ofbiophysical research and deepen their understanding of the functions ofbiological macromolecules and their regulation through quantitative analysis oflife processes and the development of simple biophysical models, thus helpingstudents to build a better knowledge system and solidify the foundations ofscientific research. We will start by introducing some facts to gain aquantitative understanding of biological phenomena. Next, we will examine thephysical and chemical properties of biological membranes, and the energy transferand movement characteristics of biological systems. Then, we will focus on aseries of techniques that have driven advances in studying the structure andfunction of proteins and nucleic acids. Finally, we will introduce proteinfolding mechanisms, review advances in the study of amyloid filaments andprotein assemblies driven by liquid-liquid phase separation.
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