生物医学组学数据分析 (帅世民)MED50202024春 2023春 2022春  
2024春 2023春 2022春
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选课类别:专业任务 教学语言:英文
课程类别:专业选修课 开课单位:医学院
课程层次:研究生 获得学分:3.0
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课程简介(教工部数据)
从人类基因组2001年问世以来,相关组学技术快速发展。面对测序获得的庞大数据,如何有效分析是不少科研人员在实际研究中经常遇到的问题。《生物医学组学数据分析》专注于组学技术在生物医学研究中的应用。本课程强调实际操作,旨在教会学生基本的组学数据分析流程。在学完本课程后,学生能掌握基本的Unix环境和R语言编程技巧,并能使用Shell和Bioconductor来初步处理课题中碰到的常见组学数据(全基因组/外显组测序、RNA-Seq、单细胞RNA-Seq、ChIP-Seq、ATAC-Seq等);或者能更好地知晓自己的分析需求,从而与生物信息学家能更高效地沟通。除此之外,本课程还希望教会学生常见的数据分析方法背后的大致原理(不涉及算法细节),让学生了解相关数据分析步骤背后的理由和逻辑。最后,本课程还希望教会学生如何更好地设计组学实验从而让之后的分析变得轻松、让结论更可靠。


Sincethe advent of the human genome in 2001, related omics technologies havedeveloped rapidly. Facing the huge data obtained by sequencing, how toeffectively analyze them are a problem that many researchers often encounter indaily research.Biomedical Omics Data Analysis focuseson the applications of omics technologies in biomedical research. This coursealso emphasizes hands-on experience with the aim to teach students thebasic omics data analysis workflow. After completing this course, students areexpected to masterthe basic Unix environment and R language programming skills, and can use Shelland Bioconductor to process common omics data encountered in their thesisresearch (whole genome/exome sequencing, RNA-Seq, Single-cell RNA-Seq,ChIP-Seq, ATAC-Seq, long-read sequencing etc.); or can better understand theiranalysis needs, so that they can communicate with bioinformaticians moreefficiently. In addition, this course also aims to teach students the generalprinciples behind common data analysis methods without getting into too many algorithmicdetails, so that students can understand the reasoning and logics behind eachanalysis step. Finally, this course also hopes to teach students how to betterdesign omics experiments to make subsequent analysis easier and makeconclusions more reliable.
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帅世民

人类细胞生物和遗传学系

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