With the success ofHuman Genome Project, medical life sciences entered the “post-genomic era”,have achieved rapid advancement in Functional Genomics & Systems Biology,and invented multiple cutting-edge multi-Omics technologies, e.g. thehigh-throughput DNA sequencing technologies, single cell-based omics tools, andthe numerous bioinformatics tools/databases. These kind of multi-Omics big datahas opened the chance to investigate complex biological networks at globallevel, and to achieve the most efficient therapy through personalized medicine,namely “Precision Medicine” (PM). This course delivers two main modules aboutPM: 1)Composition of multi-omics big data & omics tools in PrecisionMedicine, including concept of multi-omics, technological development &characteristics for big data production and analyses; 2)Case studies ofapplication of multi-omics tools and big data for PM on clinic. Within this course, students will be proficient in thebasic concepts and knowledge of multi-Omics that are emerging in thepost-Genomic era, in particular, the cutting-edge omics tools in the context ofgenomics, transcriptomics, epigenomics, proteomics, metabolomics, and phenomics,and also learn to use them to study disease development and genetic/non-geneticvariation of individual differences in therapeutic response. In addition,students can learn multiple clinical cases of precision medicine in treatingdifferent types of diseases, and master the status, prospects, opportunitiesand challenges, ethics, etc. of pharmacogenomics and precision medicine, andexpress their own insights.This course can promote the basic education on functional genomics,multi-omics in the post-genome era and opportunities and challenges ofprecision medicine. Students can learn the cutting-edge omics emerging in thepast 20 years, grasp the contents, big data composition, future, and challengesof PM as the new direction of clinical therapy. This course makes them capableof understanding and designing multi-omics tools as well as big data analyses,and thus facilitate their basic and translational medical or life sciences. Italso serves as the course foundation for understanding the recent advancementsin specified clinical medical subjects.