遗传流行病学

This course combines genomics and epidemiologyfor studying the core issues of public health, especially the determinants ofnon-communicable diseases. This course emphasizes the use of genomics toanalyze genetic variation frequency and disease frequency to gain insights intoetiologies of major diseases that are of public health concern. Topics includeoverview of genetics and etiology of non-communicable diseases, geneticmutation and variation in families and in global populations, the investigationof multifactorial complex traits especially cardiometabolic diseases andcancers, gene-gene interactions and gene-environment interactions. Analyticmethods to be demonstrated include genome-wide association studies, polygenicrisk scores, mendelian randomization, and many other system epidemiologyapproaches.