Thiscourse provides in-depth learning on genomics big data and practicalapplications in the field of biomedicine. Different from bioinformatics coursesthat focus on software development and application, and different from medicalgenetics courses that focus on biological technology and genetic diseases, thiscourse focuses on genomics and other multi-omics big data analyses. This courseuse research papers published in top journals as the main learning reference materials.It combines theory and practice to improve students' scientific researchthinking and analytical skills.