BIO102B is an introductory/discovery course for freshmen（but not limited to）to understand biology through laying out some major modern-day issues that we and other species of the planet have been facing. In the past half century, the biological and biomedical research represents an actively evolved rapidly progressed scientific field to expand and somehow to quick subvert traditional and contemporary knowledge of life. The course is thus intended to explain why the field is challenging and requires an enormous effort of inter-disciplines (including but not restricted to the chemistry, physics, mathematics, medicine, computer science, health science and material science) and why biotech and biomedical research has been heavily invested in developed countries around the world. Unlike the stereotype of biology course, i.e., applying a few theorems or rules and memorizing lots of names, terms and facts, BIO102B would guide the students to experience a new learning journey of life science, and to cherish, revere and appreciate life more.